The 27 Club's tragedies are rooted in common themes. Many of the musicians were disillusioned with their newly found fame and turned to drugs and alcohol to cope with their depression. Kurt Cobain and Amy Winehouse are prime examples of two musicians that learned to cope through the use of drugs and alcohol. Amy Winehouse struggled with fame from an early age, and even expressed her fears she would become a part of the 27 club. Her eating disorder combined with her drug habits eventually led to her early demise. Those who died from overdoses and suicide were often found dead far from home. For example, Kristen Pfaff died of a heroin overdose in 1994, and she was found all the way across the country from her hometown of Buffalo, New York. Another example of increased isolation leading to early death is Jimi Hendrix who died of a drug overdose in 1970. He was found dead in the United Kingdom, thousands of miles from his hometown of Seattle, Washington. Janis Joplin was another victim of isolation and overdose. She was born in Port Arthur, Texas, but she died of a drug overdose over 1,500 miles from home in Los Angeles, California in 1970. Therefore, it can be inferred that the increased isolation due to demanding careers led them to their untimely demise and their induction into the club.

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